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Other Health Benefits and Special Considerations

Certain medications may interfere with folate absorption, metabolism, or excretion. These include anti-seizure medications, certain antibiotics, medications used to treat rheumatoid arthritis or cancer, and certain anti-inflammatory medications. Individuals taking these medications may have a higher folate requirement.

Potential Drug Interactions with Folate

Drug Category or Treatment Examples*
Antacids, Anti-ulcer Histamine-2 blockers, proton pump inhibitors
Antibiotics Combination of Trimethoprim and a sulfonamide (Bactrim®, Septra®)
Anticancer Methotrexate, Aminopterin
Anticonvulsants, antiseizure Phenobarbital, Phenytoin (Dilantin®), Carbamazepine (Tegretol®), Primidone (Mysoline®), Valproic acid (Depakene®)
Antihistamines Cimetidine (Tagamet®)
Anti-inflammatory Sulfasalazine (Azulfidine®)
Antimalarial Pyrimethamine
Beta-blockers and calcium-channel blockers Some medications used to treat high blood pressure or other heart conditions
Diabetes Metformin
Diuretics Triamterene
Hypercholesterolemia Cholestyramine (Locholest®, Questran®)
Non-steroidal anti-inflammatory drugs (NSAIDS) Aspirin, Ibuprofen
Rheumatoid arthritis Methotrexate
Sulfonamides Sulfamethoxazole, sulfamethazine

(Bailey et al., 2001; Cabrera et al., 2004)
*This list is not all inclusive

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